December 13, 2009

Buprenorphine Overdose with Lisa Booze and Episode 197

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EMS News—

Paramedic Had Hands in Pocket While Patient Suffers Heart Attack

Nine EMTs To Be Out of Work

Rescuers To Avoid Flu Cases in Lowell, Massachussetts

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Tip This Week — Buprenorphine Overdose with Lisa Booze of Maryland Poison Center

Buprenorphine, more popularly known as Subutex, is an opioid partial agonist used to treat opioid dependence such as addiction to narcotic analgesics, heroine, or any drug with an opioid formulation. Suboxone, is buprenophrine added with naloxone to decrease the likelihood of diversion and abuse of the combination product.

Ideal candidates for Buprenorphine therapy are chosen following a criteria and three phases of maintenance therapy are followed. The dose of Buprenorphine given in each phase of the therapy is closely monitored by the physician and adjusted through the progression of each phase until medically supervise withdrawal (formerly called detoxification) is achieved.

providers responding to Buprenorphine users with pinpoint pupils, extreme drowsiness, dizziness, blurred vision and slowed breathing should suspect drug overdose. Emergency measures should be directed at providing a patent airway for the patient, careful monitoring of respiratory and cardiac status and immediate transport to a health facility. If overdosed with parenteral form of the drug, paramedics should remember that Naloxone may not be effective in reversing respiratory depression. Doxapram, a respiratory stimulant, may be used. Oxygen, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated.

Buprenorphine (Sublingual) by NIH MedlinePlus

US Dept. of Health and Human Services on Buprenorphine Therapy

DailyMed on Buprenorphine Hydrochloride Injection

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